Citrus reticulata peel oil as an antiatherogenic agent: Hypolipogenic effect in hepatic cells, lipid storage decrease in foam cells, and prevention of LDL oxidation.
Identifieur interne : 000197 ( Main/Exploration ); précédent : 000196; suivant : 000198Citrus reticulata peel oil as an antiatherogenic agent: Hypolipogenic effect in hepatic cells, lipid storage decrease in foam cells, and prevention of LDL oxidation.
Auteurs : María A. Castro [Argentine] ; Manuel A. Llanos [Argentine] ; Boris E. Rodenak-Kladniew [Argentine] ; Luciana Gavernet [Argentine] ; Marianela E. Galle [Argentine] ; Rosana Crespo [Argentine]Source :
- Nutrition, metabolism, and cardiovascular diseases : NMCD [ 1590-3729 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antigènes CD36 (métabolisme), Antioxydants (isolement et purification), Antioxydants (pharmacologie), Athérosclérose (métabolisme), Athérosclérose (prévention et contrôle), Athérosclérose (étiologie), Cellules HepG2 (MeSH), Cellules RAW 264.7 (MeSH), Cellules spumeuses (effets des médicaments et des substances chimiques), Cellules spumeuses (métabolisme), Cholestérol (métabolisme), Citrus (composition chimique), Dyslipidémies (complications), Dyslipidémies (métabolisme), Dyslipidémies (traitement médicamenteux), Fruit (composition chimique), Huiles végétales (isolement et purification), Huiles végétales (pharmacologie), Humains (MeSH), Hypolipémiants (isolement et purification), Hypolipémiants (pharmacologie), Hépatocytes (effets des médicaments et des substances chimiques), Hépatocytes (métabolisme), Intramolecular transferases (antagonistes et inhibiteurs), Intramolecular transferases (métabolisme), Lipoprotéines LDL (métabolisme), Peroxydation lipidique (effets des médicaments et des substances chimiques), Simulation de docking moléculaire (MeSH), Souris (MeSH).
- MESH :
- antagonistes et inhibiteurs : Intramolecular transferases.
- composition chimique : Citrus, Dyslipidémies, Fruit.
- effets des médicaments et des substances chimiques : Cellules spumeuses, Hépatocytes, Peroxydation lipidique.
- isolement et purification : Antioxydants, Huiles végétales, Hypolipémiants.
- métabolisme : Antigènes CD36, Athérosclérose, Cellules spumeuses, Cholestérol, Dyslipidémies, Hépatocytes, Intramolecular transferases, Lipoprotéines LDL.
- pharmacologie : Antioxydants, Huiles végétales, Hypolipémiants.
- prévention et contrôle : Athérosclérose.
- traitement médicamenteux : Dyslipidémies.
- étiologie : Athérosclérose.
- Animaux, Cellules HepG2, Cellules RAW 264.7, Humains, Simulation de docking moléculaire, Souris.
English descriptors
- KwdEn :
- Animals (MeSH), Antioxidants (isolation & purification), Antioxidants (pharmacology), Atherosclerosis (etiology), Atherosclerosis (metabolism), Atherosclerosis (prevention & control), CD36 Antigens (metabolism), Cholesterol (metabolism), Citrus (chemistry), Dyslipidemias (complications), Dyslipidemias (drug therapy), Dyslipidemias (metabolism), Foam Cells (drug effects), Foam Cells (metabolism), Fruit (chemistry), Hep G2 Cells (MeSH), Hepatocytes (drug effects), Hepatocytes (metabolism), Humans (MeSH), Hypolipidemic Agents (isolation & purification), Hypolipidemic Agents (pharmacology), Intramolecular Transferases (antagonists & inhibitors), Intramolecular Transferases (metabolism), Lipid Peroxidation (drug effects), Lipoproteins, LDL (metabolism), Mice (MeSH), Molecular Docking Simulation (MeSH), Plant Oils (isolation & purification), Plant Oils (pharmacology), RAW 264.7 Cells (MeSH).
- MESH :
- chemical , antagonists & inhibitors : Intramolecular Transferases.
- chemical , isolation & purification : Antioxidants, Hypolipidemic Agents, Plant Oils.
- chemical , metabolism : CD36 Antigens, Cholesterol, Intramolecular Transferases, Lipoproteins, LDL.
- chemical , pharmacology : Antioxidants, Hypolipidemic Agents, Plant Oils.
- chemistry : Citrus, Fruit.
- complications : Dyslipidemias.
- drug effects : Foam Cells, Hepatocytes, Lipid Peroxidation.
- drug therapy : Dyslipidemias.
- etiology : Atherosclerosis.
- metabolism : Atherosclerosis, Dyslipidemias, Foam Cells, Hepatocytes.
- prevention & control : Atherosclerosis.
- Animals, Hep G2 Cells, Humans, Mice, Molecular Docking Simulation, RAW 264.7 Cells.
Abstract
BACKGROUND AND AIMS
Hypercholesterolemia and oxidative stress are two of the most important risk factors for atherosclerosis. The aim of the present work was to evaluate mandarin (Citrus reticulata) peel oil (MPO) in cholesterol metabolism and lipid synthesis, and its antioxidant capacity.
METHODS AND RESULTS
Incubation of hepatic HepG2 cells with MPO (15-60 μL/L) reduced cholesterogenesis and saponifiable lipid synthesis, demonstrated by [
CONCLUSION
These results may imply a potential role of MPO in preventing atherosclerosis by a mechanism involving inhibition of lipid synthesis and storage and the decrease of LDL lipid peroxidation.
DOI: 10.1016/j.numecd.2020.04.033
PubMed: 32605883
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Castro</name><affiliation wicri:level="1"><nlm:affiliation>INIBIOLP (La Plata Biochemical Research Institute), CONICET-CCT La Plata, School of Medical Sciences, UNLP, 60 y 120 (1900), La Plata, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>INIBIOLP (La Plata Biochemical Research Institute), CONICET-CCT La Plata, School of Medical Sciences, UNLP, 60 y 120 (1900), La Plata</wicri:regionArea><wicri:noRegion>La Plata</wicri:noRegion></affiliation></author><author><name sortKey="Llanos, Manuel A" sort="Llanos, Manuel A" uniqKey="Llanos M" first="Manuel A" last="Llanos">Manuel A. 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(chemistry)</term><term>Dyslipidemias (complications)</term><term>Dyslipidemias (drug therapy)</term><term>Dyslipidemias (metabolism)</term><term>Foam Cells (drug effects)</term><term>Foam Cells (metabolism)</term><term>Fruit (chemistry)</term><term>Hep G2 Cells (MeSH)</term><term>Hepatocytes (drug effects)</term><term>Hepatocytes (metabolism)</term><term>Humans (MeSH)</term><term>Hypolipidemic Agents (isolation & purification)</term><term>Hypolipidemic Agents (pharmacology)</term><term>Intramolecular Transferases (antagonists & inhibitors)</term><term>Intramolecular Transferases (metabolism)</term><term>Lipid Peroxidation (drug effects)</term><term>Lipoproteins, LDL (metabolism)</term><term>Mice (MeSH)</term><term>Molecular Docking Simulation (MeSH)</term><term>Plant Oils (isolation & purification)</term><term>Plant Oils (pharmacology)</term><term>RAW 264.7 Cells (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Antigènes CD36 (métabolisme)</term><term>Antioxydants (isolement et purification)</term><term>Antioxydants (pharmacologie)</term><term>Athérosclérose (métabolisme)</term><term>Athérosclérose (prévention et contrôle)</term><term>Athérosclérose (étiologie)</term><term>Cellules HepG2 (MeSH)</term><term>Cellules RAW 264.7 (MeSH)</term><term>Cellules spumeuses (effets des médicaments et des substances chimiques)</term><term>Cellules spumeuses (métabolisme)</term><term>Cholestérol (métabolisme)</term><term>Citrus (composition chimique)</term><term>Dyslipidémies (complications)</term><term>Dyslipidémies (métabolisme)</term><term>Dyslipidémies (traitement médicamenteux)</term><term>Fruit (composition chimique)</term><term>Huiles végétales (isolement et purification)</term><term>Huiles végétales (pharmacologie)</term><term>Humains (MeSH)</term><term>Hypolipémiants (isolement et purification)</term><term>Hypolipémiants (pharmacologie)</term><term>Hépatocytes (effets des médicaments et des substances chimiques)</term><term>Hépatocytes (métabolisme)</term><term>Intramolecular transferases (antagonistes et inhibiteurs)</term><term>Intramolecular transferases (métabolisme)</term><term>Lipoprotéines LDL (métabolisme)</term><term>Peroxydation lipidique (effets des médicaments et des substances chimiques)</term><term>Simulation de docking moléculaire (MeSH)</term><term>Souris (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Intramolecular Transferases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antioxidants</term><term>Hypolipidemic Agents</term><term>Plant Oils</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>CD36 Antigens</term><term>Cholesterol</term><term>Intramolecular Transferases</term><term>Lipoproteins, LDL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antioxidants</term><term>Hypolipidemic Agents</term><term>Plant Oils</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Intramolecular transferases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus</term><term>Fruit</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dyslipidemias</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Citrus</term><term>Dyslipidémies</term><term>Fruit</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Foam Cells</term><term>Hepatocytes</term><term>Lipid Peroxidation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dyslipidemias</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cellules spumeuses</term><term>Hépatocytes</term><term>Peroxydation lipidique</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antioxydants</term><term>Huiles végétales</term><term>Hypolipémiants</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Atherosclerosis</term><term>Dyslipidemias</term><term>Foam Cells</term><term>Hepatocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes CD36</term><term>Athérosclérose</term><term>Cellules spumeuses</term><term>Cholestérol</term><term>Dyslipidémies</term><term>Hépatocytes</term><term>Intramolecular transferases</term><term>Lipoprotéines LDL</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antioxydants</term><term>Huiles végétales</term><term>Hypolipémiants</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Athérosclérose</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Dyslipidémies</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Athérosclérose</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Hep G2 Cells</term><term>Humans</term><term>Mice</term><term>Molecular Docking Simulation</term><term>RAW 264.7 Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules HepG2</term><term>Cellules RAW 264.7</term><term>Humains</term><term>Simulation de docking moléculaire</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND AND AIMS</b></p><p>Hypercholesterolemia and oxidative stress are two of the most important risk factors for atherosclerosis. The aim of the present work was to evaluate mandarin (Citrus reticulata) peel oil (MPO) in cholesterol metabolism and lipid synthesis, and its antioxidant capacity.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS AND RESULTS</b></p><p>Incubation of hepatic HepG2 cells with MPO (15-60 μL/L) reduced cholesterogenesis and saponifiable lipid synthesis, demonstrated by [</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>These results may imply a potential role of MPO in preventing atherosclerosis by a mechanism involving inhibition of lipid synthesis and storage and the decrease of LDL lipid peroxidation.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32605883</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>09</Day></DateCompleted><DateRevised><Year>2020</Year><Month>11</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1590-3729</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>08</Month><Day>28</Day></PubDate></JournalIssue><Title>Nutrition, metabolism, and cardiovascular diseases : NMCD</Title><ISOAbbreviation>Nutr Metab Cardiovasc Dis</ISOAbbreviation></Journal><ArticleTitle>Citrus reticulata peel oil as an antiatherogenic agent: Hypolipogenic effect in hepatic cells, lipid storage decrease in foam cells, and prevention of LDL oxidation.</ArticleTitle><Pagination><MedlinePgn>1590-1599</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0939-4753(20)30156-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.numecd.2020.04.033</ELocationID><Abstract><AbstractText Label="BACKGROUND AND AIMS">Hypercholesterolemia and oxidative stress are two of the most important risk factors for atherosclerosis. The aim of the present work was to evaluate mandarin (Citrus reticulata) peel oil (MPO) in cholesterol metabolism and lipid synthesis, and its antioxidant capacity.</AbstractText><AbstractText Label="METHODS AND RESULTS">Incubation of hepatic HepG2 cells with MPO (15-60 μL/L) reduced cholesterogenesis and saponifiable lipid synthesis, demonstrated by [<sup>14</sup>C]acetate radioactivity assays. These effects were associated with a decrease in a post-squalene reaction of the mevalonate pathway. Molecular docking analyses were carried out using three different scoring functions to examine the cholesterol-lowering property of all the components of MPO against lanosterol synthase. Docking simulations proposed that minor components of MPO monoterpenes, like alpha-farnesene and neryl acetate, as well the major component, limonene and its metabolites, could be partly responsible for the inhibitory effects observed in culture assays. MPO also decreased RAW 264.7 foam cell lipid storage and its CD36 expression, and prevented low-density lipoprotein (LDL) lipid peroxidation.</AbstractText><AbstractText Label="CONCLUSION">These results may imply a potential role of MPO in preventing atherosclerosis by a mechanism involving inhibition of lipid synthesis and storage and the decrease of LDL lipid peroxidation.</AbstractText><CopyrightInformation>Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Castro</LastName><ForeName>María A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>INIBIOLP (La Plata Biochemical Research Institute), CONICET-CCT La Plata, School of Medical Sciences, UNLP, 60 y 120 (1900), La Plata, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Llanos</LastName><ForeName>Manuel A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>LIDeB (Laboratory of Bioactive Research and Development), Medicinal Chemistry, Department of Biological Sciences, School of Exact Sciences, UNLP, 47 y 115 (1900), La Plata, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodenak-Kladniew</LastName><ForeName>Boris E</ForeName><Initials>BE</Initials><AffiliationInfo><Affiliation>INIBIOLP (La Plata Biochemical Research Institute), CONICET-CCT La Plata, School of Medical Sciences, UNLP, 60 y 120 (1900), La Plata, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gavernet</LastName><ForeName>Luciana</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>LIDeB (Laboratory of Bioactive Research and Development), Medicinal Chemistry, Department of Biological Sciences, School of Exact Sciences, UNLP, 47 y 115 (1900), La Plata, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galle</LastName><ForeName>Marianela E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>INIBIOLP (La Plata Biochemical Research Institute), CONICET-CCT La Plata, School of Medical Sciences, UNLP, 60 y 120 (1900), La Plata, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crespo</LastName><ForeName>Rosana</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>INIBIOLP (La Plata Biochemical Research Institute), CONICET-CCT La Plata, School of Medical Sciences, UNLP, 60 y 120 (1900), La Plata, Argentina. Electronic address: rosana.crespo@unc.edu.ar.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Nutr Metab Cardiovasc Dis</MedlineTA><NlmUniqueID>9111474</NlmUniqueID><ISSNLinking>0939-4753</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018955">CD36 Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C000632513">Cd36 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000960">Hypolipidemic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008077">Lipoproteins, LDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010938">Plant Oils</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C099252">oxidized low density lipoprotein</NameOfSubstance></Chemical><Chemical><RegistryNumber>97C5T2UQ7J</RegistryNumber><NameOfSubstance UI="D002784">Cholesterol</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 5.4.-</RegistryNumber><NameOfSubstance UI="D019751">Intramolecular Transferases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 5.4.99.7</RegistryNumber><NameOfSubstance UI="C021924">lanosterol synthase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050197" MajorTopicYN="N">Atherosclerosis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018955" MajorTopicYN="N">CD36 Antigens</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002784" MajorTopicYN="N">Cholesterol</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002957" MajorTopicYN="Y">Citrus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050171" MajorTopicYN="N">Dyslipidemias</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005487" MajorTopicYN="N">Foam Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="Y">Fruit</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056945" MajorTopicYN="N">Hep G2 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D022781" MajorTopicYN="N">Hepatocytes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000960" MajorTopicYN="N">Hypolipidemic Agents</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019751" MajorTopicYN="N">Intramolecular Transferases</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015227" MajorTopicYN="N">Lipid Peroxidation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008077" MajorTopicYN="N">Lipoproteins, LDL</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D062105" MajorTopicYN="N">Molecular Docking Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010938" MajorTopicYN="N">Plant Oils</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000067996" MajorTopicYN="N">RAW 264.7 Cells</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Citrus reticulata peel oil</Keyword><Keyword MajorTopicYN="Y">Docking</Keyword><Keyword MajorTopicYN="Y">Foam cells</Keyword><Keyword MajorTopicYN="Y">Hepatic cells</Keyword><Keyword MajorTopicYN="Y">Lanosterol synthase</Keyword><Keyword MajorTopicYN="Y">Lipid metabolism</Keyword></KeywordList><CoiStatement>Declaration of Competing Interest The authors declare no conflicts of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>10</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>04</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32605883</ArticleId><ArticleId IdType="pii">S0939-4753(20)30156-3</ArticleId><ArticleId IdType="doi">10.1016/j.numecd.2020.04.033</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Argentine</li></country></list><tree><country name="Argentine"><noRegion><name sortKey="Castro, Maria A" sort="Castro, Maria A" uniqKey="Castro M" first="María A" last="Castro">María A. Castro</name></noRegion><name sortKey="Crespo, Rosana" sort="Crespo, Rosana" uniqKey="Crespo R" first="Rosana" last="Crespo">Rosana Crespo</name><name sortKey="Galle, Marianela E" sort="Galle, Marianela E" uniqKey="Galle M" first="Marianela E" last="Galle">Marianela E. Galle</name><name sortKey="Gavernet, Luciana" sort="Gavernet, Luciana" uniqKey="Gavernet L" first="Luciana" last="Gavernet">Luciana Gavernet</name><name sortKey="Llanos, Manuel A" sort="Llanos, Manuel A" uniqKey="Llanos M" first="Manuel A" last="Llanos">Manuel A. Llanos</name><name sortKey="Rodenak Kladniew, Boris E" sort="Rodenak Kladniew, Boris E" uniqKey="Rodenak Kladniew B" first="Boris E" last="Rodenak-Kladniew">Boris E. Rodenak-Kladniew</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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